The C-reactive protein, an acute phase protein, is an abnormal protein absent from normal human serum.
It is, in all likelihood, a globulin formed by the body in response to various non-specific stimuli such as an infections, tissue necrosis, trauma, neoplasm and granuloma formation.
The existence of this protein was first recognized by Tillet and Francis in 1930, as a result of its property of reacting to form a precipitate in the presence of the somatic C-polysaccharide of the pneumococcus.
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